Background: Currently, diabetes is one of the most common diseases that has a devastating effect on the body and causes free radicals in the body. One of the most important organs in the body that metabolizes and analyzes hormones and various substances is the liver (the largest gland of the body. Therefore, in order to cope with the damaging effects of diabetes and its effect on some liver enzymes, strong antioxidants have been needed. In this study, we tried to assess the effects of harmaline on albumin and some liver enzymes. Materials and Methods: In this study, 35 male vistar rats with a weight range of 180-200 g were divided into five groups of seven in control group (that received citrate buffer as they became diabetic) and case group (diabetic with intraperitoneal injection of 55 mg/kg streptozotocin), experimental group 1 (diabetic and subcutaneously receiving 10 mg/kg harmaline), experimental group 2 (diabetic and received subcutaneous dose of 15 mg/kg of harmaline), and experimental group 3 (diabetic and received 20 mg/kg of harmaline subcutaneously) and After two months of becoming diabetic, rats received subcutaneous medication of various doses of harmaline for two weeks. Then, anesthesia was achieved in rats with ketamine and zylazine, and blood sampling was conducted directly from the heart. After separating serum to measure glucose and insulin, samples were delivered to the laboratory. Results: In this study, a significant decrease was observed in the amount of albumin in the experimental groups compared with the control group and a significant increase was observed in the amount of aspartate AMINOTRANSFERASE, and ALANINE AMINOTRANSFERASE enzymes in experimental groups compared with the control group. In experimental diabetic groups, the amount of albumin has also shown no significant changes compared with the other diabetic groups. Conclusion: This study showed that taking harmaline caused a disturbance in the balance of liver enzymes and elevated serum albumin levels in healthy and diabetic rats. has changed the balance of liver enzymes and increased blood albumin in healthy rats, while liver enzymes increased in diabetic groups as dosage increased.

Liver is an important organ with major role in carbohydrates, proteins and lipids metabolism. In addition, secretion and excretion of toxic materials occur in this organ. Exposure to a variety of infectious agents such as parasitic, viral, bacterial or toxic materials may lead to liver damage. Today, one of the best way for investigation and diagnosis of liver damage is measurement of some liver enzyme such as ALANINE AMINOTRANSFERASE (GPT or ALT), aspartate AMINOTRANSFERASE (GOT or AST). Since, these enzymes exist in other tissues, measurement of other specific enzyme is required. In this study activity of ornithine carbamyl transferase (OCT), the second enzyme in urea cycle, in 56 patients with liver problem (cirrhosis and viral hepatitis) was determined. SGPT, SGOT, Alb, Bil, مGT and ALP tests were performed. To assess the health and unhealthy liver in both control and sample groups. Our data shows a correlation between activity of OCT with SGOT (r=0.782, p<0.001) and with SGPT (r=0.857, p<0.001). Since OCT enzyme is specific for liver, further investigation of activity of this enzyme in assessment of other liver problems is required.

Background: A healthy diet provides the body with essential nutrition that includes fluids, macronutrients, micronutrients, and calories. The liver is one of the most important organs in the body that has the function of detoxification and cleansing, and smoking causes an additional burden for the detoxification function of the liver, which can lead to inflammation and fatty liver. This study was designed to investigate the effects of smoking on liver function. Materials and Methods: This cross-sectional descriptive-analytical study investigated the relationship between smoking and the type of nutrition of liver enzymes in healthy people and people who smoke in Zabol. In this study, 150 people were selected who were divided into two groups of healthy people without smoking (n = 75) and people with smoking with liver problems (n = 75). Results: There was no statistical relationship between age and levels of aspartate AMINOTRANSFERASE (AST) and ALANINE AMINOTRANSFERASE (ALT) liver enzymes (P > 0. 05). However, a relationship was found between weight and levels of liver enzymes AST and ALT. Hepatitis also increased (P < 0. 05), and there was a statistical relationship between alcohol consumption with AST and ALT liver enzymes,more precisely, the more alcohol consumption, the higher the amount of liver enzymes (P < 0. 05). Finally, no statistically significant relationship was observed between fruit and vegetable consumption, rice consumption, meat consumption, and water consumption (P > 0. 05). Conclusion: This relationship is positive and direct,in other words, the higher the consumption of tobacco, the higher the activity of liver enzymes ALT and AST.

Background and Objectives: Diabetes disease can have destructive effects on different organs such as the liver. At this situation, ALANINE AMINOTRANSFERASE and aspartate AMINOTRANSFERASE increase in the blood. This study aimed to review the effect of aloe vera with swimming training on ALANINE AMINOTRANSFERASE and aspartate AMINOTRANSFERASE levels of streptozotocin induced diabetic rats.Materials and Methods: 84 rats divided into seven groups; -week healthy control, fourth-week healthy control, first-week diabetic control, fourth-week diabetic control, Aloe Vera extract, swimming training, and swimming training with Aloe Vera extract. The training program included 30 minutes of swimming, three times per week, for 4 weeks. At the end, ALANINE AMINOTRANSFERASE and aspartate AMINOTRANSFERASE levels were measured by gathering blood samples from the heart. One-way ANOVA and Tukey post hoc tests were used for statistical analysis of data (a=0.05).Results: The results showed that induction of diabetes significantly increases ALANINE AMINOTRANSFERASE and aspartate AMINOTRANSFERASE (p=0.001) Also swimming training and Aloe Vera consumption for four weeks have significant effect on reduction of ALANINE AMINOTRANSFERASE and aspartate AMINOTRANSFERASE (p=0.001), whereas the four-week swimming training together with Aloe Vera consumption has more effect on the reduction of ALANINE AMINOTRANSFERASE and aspartate AMINOTRANSFERASE (p=0.001).Conclusion: It can be concluded that although swimming training and Aloe Vera consumption separately have lowering effect on ALANINE AMINOTRANSFERASE and aspartate AMINOTRANSFERASE, but swimming training together with Aloe Vera consumption has more effect on the reduction of ALANINE AMINOTRANSFERASE and aspartate AMINOTRANSFERASE.

AIM: The healthy ranges for serum ALANINE AMINOTRANSFERASE (ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1939 blood donors were included. ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels were computed from the population at lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels.RESULTS: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L, and for non-overweight men was 40 U/L.CONCLUSION: Serum ALT is strongly associated with sex and BMI The normal range of ALT should be defined for male and female separately.

Sedentariness and inactivity exposes men to various diseases and premature death. In industrialized societies, most people do not have physical activity. This way of life causes that the number of obese people, inactive people and the risk of liver diseases increase. The aim of this study was reviewing the effect of two weeks detraining after 8 weeks of aerobic training on alanin AMINOTRANSFERASE and aspartate AMINOTRANSFERASE of inactive men. In this clinical trial,18 inactive men selected and according to aerobic capacity divided to two groups of 9 subject with mean and standard deviation, of age (37.64 ± 4.7, 35.60 ± 2.54 years), weight (79.81 ± 7.66, 84.00 ± 9.79 kg) and height (173.91 ± 4.32, 175.55 ± 5.10 cm) respectively for experimental and control groups. experimental group ran on treadmill for eight weeks, three days a week and 30 minutes each session (the first week started with 50% of heart rate reserve and reached during the eight weeks to 70% of heart rate reserve), Then, training stoped for two weeks. 24 hours before the start of training, 24 hours after the last training session and two weeks after detraining period, Blood was collected from all subjects. Kolmogorov-Smirnov test, analysis of variance with repeated measures along with tukey’s post hoc test used for analysis of data(p=0.005). Results showed that detraining caused a significant increase of aspartate AMINOTRANSFERASE (p=0.005) but has no significant effect on decrease of ALANINE AMINOTRANSFERASE (p=0. 568). It can be concluded that eight weeks of selected aerobic training caused changes in the level of liver enzymes and also two weeks of detraining cause changes in the level of liver enzymes.